Forensic characteristics and genetic analysis of both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese population

Min Lang; Hai Liu; Feng Song; Xianhua Qiao; Yi Ye; He Ren; Jienan Li; Jian Huang; Mingkun Xie; Shengjie Chen; Mengyuan Song; Youfang Zhang; Xiaoqin Qian; Taoxiu Yuan; Zheng Wang; Yuming Liu; Mengge Wang; Yacheng Liu; Jing Liu; Yiping Hou

doi:10.1016/j.fsigen.2019.07.011

Forensic characteristics and genetic analysis of both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese population

Forensic Sci Int Genet. 2019 Sep:42:e13-e20. doi: 10.1016/j.fsigen.2019.07.011. Epub 2019 Jul 23.

Authors

Min Lang¹, Hai Liu², Feng Song¹, Xianhua Qiao², Yi Ye¹, He Ren³, Jienan Li¹, Jian Huang⁴, Mingkun Xie¹, Shengjie Chen⁵, Mengyuan Song¹, Youfang Zhang⁶, Xiaoqin Qian¹, Taoxiu Yuan⁷, Zheng Wang¹, Yuming Liu⁸, Mengge Wang¹, Yacheng Liu⁹, Jing Liu¹, Yiping Hou¹⁰

Affiliations

¹ Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
² The Institute of Forensic Science and Technology, Henan Provincial Public Security Bureau, Zhengzhou 450003, China.
³ Beijing Police College, Beijing 102202, China.
⁴ Department of Forensic genetics, Brain Hospital of Hunan Province, Hunan University of Chinese Medicine, Changsha 410007, China.
⁵ Criminal Detection Unit of Qingxiu District Public Security Sub-bureau in Nanning, Nanning 530000, China.
⁶ Department of Forensic Science, Zhejiang Police College, Hangzhou 310053, China.
⁷ Forensic Science Institute of Zhejiang Di'an Diagnosis Technology Co., Ltd, Hangzhou 310012, China.
⁸ Forensic Science Center Zhongding Guangdong, Zhanjiang 524000, China.
⁹ Beijing Tongda Shoucheng Institute of Forensic Science, Beijing 100085, China.
¹⁰ Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China. Electronic address: forensic@scu.edu.cn.

PMID: 31353318
DOI: 10.1016/j.fsigen.2019.07.011

Abstract

Y-chromosome short tandem repeat (Y-STR) and Y-chromosome single nucleotide polymorphism (Y-SNP) frequency distributions provide resources for assessment of male population stratification among world-wide populations. Currently, the Y-STR Haplotype Reference Database (YHRD) contains numerous Y-chromosome haplotype profiles from various populations and countries around the world. However, for many of the recently discovered and already phylogenetically mapped Y-SNPs, the population data are scarce. Herein, the typing of 27 Y-STRs (Yfiler Plus) and 143 Y-SNPs (self-designed Y-SNP panel) was performed on 1269 unrelated males from 11 Han Chinese populations. Haplogroup O-M175 was the most predominant haplogroup in our Han Chinese data, ranging from 67.34% (Henan Han) to 93.16% (Guangdong Han). The highest haplogroup diversity (0.967056) was observed in Heilongjiang Han, with a discrimination capacity (DC) value of 0.3723. The number of alleles at single-copy loci varied from 2 for DYS391 (Guangdong Han) to 16 for DYS518 (Henan Han). For the majority of the populations (8/11), both the haplotype diversity and DC values are 1.0000. Furthermore, genetic differentiations were observed between Northern and Southern Han Chinese. These genetic differences were mainly reflected in haplogroup distribution and frequency, and they were confirmed by statistical analysis.

Keywords: Han Chinese; Y-chromosome SNP; Y-chromosome STR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
China
Chromosomes, Human, Y*
DNA Fingerprinting
Ethnicity / genetics*
Genetics, Population*
Haplotypes
Humans
Male
Microsatellite Repeats*
Phylogeny
Polymorphism, Single Nucleotide*