Prevalence of acquired resistance mutations in a large cohort of perinatally infected HIV-1 patients

R Ungaro; L Taramasso; B Bruzzone; I Vicenti; L Galli; V Borghi; D Francisci; M Pecorari; A Zoncada; A P Callegaro; E Paolini; L Monno; S Bonora; A Di Biagio; ARCA Study Group

doi:10.1016/j.cmi.2019.07.004

Prevalence of acquired resistance mutations in a large cohort of perinatally infected HIV-1 patients

Clin Microbiol Infect. 2019 Nov;25(11):1443-1446. doi: 10.1016/j.cmi.2019.07.004. Epub 2019 Jul 25.

Authors

R Ungaro¹, L Taramasso², B Bruzzone³, I Vicenti⁴, L Galli⁵, V Borghi⁶, D Francisci⁷, M Pecorari⁸, A Zoncada⁹, A P Callegaro¹⁰, E Paolini¹¹, L Monno¹², S Bonora¹³, A Di Biagio¹⁴; ARCA Study Group

Collaborators

ARCA Study Group:
Andrea Giacometti¹⁵, Luca Butini¹⁶, Romana Del Gobbo¹⁷, Patrizia Bagnarelli¹⁸, Danilo Tacconi¹⁹, Giovanni Corbelli²⁰, Stefania Zanussi²¹, Laura Monno²², Grazia Punzi²³, Franco Maggiolo²⁴, Leonardo Calza²⁵, Maria Carla Re²⁶, Raffaele Pristera²⁷, Paola Turconi²⁸, Antonella Mandas²⁹, Sauro Tini³⁰, Alessia Zoncada³¹, Elisabetta Paolini³², Giorgio Amadio³³, Laura Sighinolfi³⁴, Paola Corsi³⁵, Luisa Galli³⁶, Massimo Di Pietro³⁷, Grazia Colao³⁸, Andrea Tosti³⁹, Maurizio Setti⁴⁰, Bianca Bruzzone⁴¹, Antonio Di Biagio⁴², Giovanni Cenderello⁴³, Michele Trezzi⁴⁴, Anna Orani⁴⁵, Irene Arcidiacono⁴⁶, Alberto Degiuli⁴⁷, Michele De Gennaro⁴⁸, Alessandro Chiodera⁴⁹, Alfredo Scalzini⁵⁰, Loredana Palvarini⁵¹, Giovanni Todaro⁵², Stefano Rusconi⁵³, Maria Rita Gismondo⁵⁴, Valeria Micheli⁵⁵, Maria Luisa Biondi⁵⁶, Amedeo Capetti⁵⁷, Paola Meraviglia⁵⁸, Enzo Boeri⁵⁹, Cristina Mussini⁶⁰, Monica Pecorari⁶¹, Alessandro Soria⁶², Laura Vecchi⁶³, Maurizio Santirocchi⁶⁴, Diego Brustia⁶⁵, Paolo Ravanini⁶⁶, Federico Dal Bello⁶⁷, Nino Romano⁶⁸, Salvatrice Mancuso⁶⁹, Carlo Calzetti⁷⁰, Renato Maserati⁷¹, Gaetano Filice⁷², Fausto Baldanti⁷³, Daniela Francisci⁷⁴, Giustino Parruti⁷⁵, Ennio Polilli⁷⁶, Daria Sacchini⁷⁷, Chiara Martinelli⁷⁸, Rita Consolini⁷⁹, Linda Vatteroni⁸⁰, Angela Vivarelli⁸¹, Alessandro Nerli⁸², Lucia Lenzi⁸³, Giacomo Magnani⁸⁴, Patrizia Ortolani⁸⁵, Massimo Andreoni⁸⁶, Caterina Fimiani⁸⁷, Lucia Palmisano⁸⁸, Simona Di Giambenedetto⁸⁹, Vincenzo Vullo⁹⁰, Ombretta Turriziani⁹¹, Marco Montano⁹², Andrea Antinori⁹³, Mauro Zaccarelli⁹³, Chiara Dentone⁹⁴, Angela Gonnelli⁹⁵, Andrea De Luca⁹⁶, Michele Palumbo⁹⁷, Valeria Ghisetti⁹⁸, Stefano Bonora⁹⁹, Palma Delle Foglie¹⁰⁰, Cristina Rossi¹⁰¹, Vincenzo Mondino¹⁰², Marina Malena¹⁰³, Paolo Grossi¹⁰⁴, Elena Seminari¹⁰⁵, Federica Poletti¹⁰⁶

Affiliations

¹ Infectious Diseases Clinic, University of Genova (DISSAL), Hospital Policlinico San Martino, Genova, Italy.
² Infectious Diseases Clinic, University of Genova (DISSAL), Hospital Policlinico San Martino, Genova, Italy; Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
³ Hygiene Unit, Hospital Policlinico San Martino, Genova, Italy.
⁴ Department of Medical Biotechnologies, University of Siena, Siena, Italy.
⁵ Department of Health Sciences, University of Florence, Meyer Children's Hospital, Florence, Italy.
⁶ Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.
⁷ Infectious Diseases Clinic, Department of Medicine, University of Perugia, Perugia, Italy.
⁸ Microbiology and Virology Unit, Azienda Ospedaliera Universitaria di Modena, Modena, Italy.
⁹ Clinic of Infectious Diseases, Cremona Hospital, Cremona, Italy.
¹⁰ Microbiology and Virology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
¹¹ Immuno-ematology and Transfusion Medicine Service, Cremona Hospital, Cremona, Italy.
¹² Department of Biomedical Sciences and Human Oncology, Clinic of Infectious Diseases, University of Bari, Italy.
¹³ Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.
¹⁴ Infectious Diseases Clinic, Policlinico Hospital San Martino, Genova, Italy. Electronic address: adibiagioa@gmail.com.
¹⁵ ANCONA-Clinica di Malattie Infettive, Italy.
¹⁶ ANCONA-Immunologia Clinica, Italy.
¹⁷ ANCONA-Malattie Infettive, Italy.
¹⁸ ANCONA-Virologia, Italy.
¹⁹ AREZZO-Malattie Infettive, Italy.
²⁰ ASCOLI PICENO-Malattie Infettive, Italy.
²¹ AVIANO Centro di Riferimento Oncologico, Italy.
²² BARI Clinica Malattie Infettive Universita', Italy.
²³ BARI-Virologia, Italy.
²⁴ BERGAMO-Malattie Infettive, Italy.
²⁵ BOLOGNA-Malattie Infettive S. Orsola, Italy.
²⁶ BOLOGNA-UO Microbiologia, Lab. Retrovirus, Italy.
²⁷ BOLZANO-Malattie Infettive, Italy.
²⁸ BRESCIA-Fleming Labs, Italy.
²⁹ CAGLIARI Centro S.I.D.A., Policlinico Universitario, Italy.
³⁰ CITTA' DI CASTELLO-Medicina Generale, Italy.
³¹ CREMONA-Malattie Infettive, Italy.
³² CREMONA-Servizio Immunoematologia e Medicina Trasfusionale, Italy.
³³ FERMO-Malattie Infettive, Italy.
³⁴ FERRARA-Malattie Infettive AOU S. Anna, Italy.
³⁵ FIRENZE-Malattie Infettive CAREGGI, Italy.
³⁶ FIRENZE-Malattie Infettive Pediatria Meyer, Italy.
³⁷ FIRENZE-Malattie Infettive SM Annunziata, Italy.
³⁸ FIRENZE-Virologia CAREGGI, Italy.
³⁹ FOLIGNO-Malattie Infettive/SERT, Italy.
⁴⁰ GENOVA Clinica Medica Immunologia, Italy.
⁴¹ GENOVA-Laboratorio di Igiene Ospedale S. Martino, Italy.
⁴² GENOVA-Malattie Infettive Ospedale S. Martino, Italy.
⁴³ GENOVA-Malattie Infettive Ospedali Galliera, Italy.
⁴⁴ GROSSETO-Malattie Infettive, Italy.
⁴⁵ LECCO-Malattie Infettive, Italy.
⁴⁶ LODI-Malattie Infettive, Italy.
⁴⁷ LODI-Virologia Lodi, Italy.
⁴⁸ LUCCA Malattie Infettive, Italy.
⁴⁹ MACERATA Malattie Infettive, Italy.
⁵⁰ MANTOVA-Malattie Infettive Ospedale 'C. Poma', Italy.
⁵¹ MANTOVA-Virologia, Italy.
⁵² MESSINA-Malattie Infettive, Italy.
⁵³ MILANODipart. Scienze Cliniche, Sez. Malattie Infettive-Universita' degli Studi, Italy.
⁵⁴ MILANO-Laboratorio Microbiologia Ospedale L. Sacco (Prima Divisione Malattie Infettive), Italy.
⁵⁵ MILANO-Laboratorio Microbiologia Ospedale L. Sacco (Seconda Divisione Malattie Infettive), Italy.
⁵⁶ MILANO Laboratorio di diagnostica molecolare infettivologica AO S. Paolo, Italy.
⁵⁷ MILANO-Prima Divisione Malattie Infettive Ospedale L. Sacco, Italy.
⁵⁸ MILANO-Seconda Divisione Malattie Infettive Ospedale L. Sacco, Italy.
⁵⁹ MILANO-Virologia HSR, Italy.
⁶⁰ MODENA-Clinica Malattie Infettive, Italy.
⁶¹ MODENA-Virologia, Italy.
⁶² MONZA-Malattie Infettive, Italy.
⁶³ MONZA-UO Microbiologia AO S. Gerardo, Italy.
⁶⁴ NARNI-SERT, Italy.
⁶⁵ NOVARA Malattie Infettive AO Maggiore, Italy.
⁶⁶ NOVARA-Virologia, Italy.
⁶⁷ PADOVA Virologia, Italy.
⁶⁸ PALERMO-Centro Riferimento AIDS Universita', Italy.
⁶⁹ PALERMO Servizio Riferimento Regionale Diagnosi AIDS, Italy.
⁷⁰ PARMA-Divisione Malattie Infettive ed Epatologia Azienda Ospedaliera, Italy.
⁷¹ PAVIA Ambulatorio Clinica Malattie Infettive S. Matteo, Italy.
⁷² PAVIA-Clinica Malattie Infettive e Tropicali, Italy.
⁷³ PAVIA-Virologia S. Matteo, Italy.
⁷⁴ PERUGIA-Malattie Infettive, Italy.
⁷⁵ PESCARA-Malattie Infettive, Italy.
⁷⁶ PESCARA Virologia Pescara, Italy.
⁷⁷ PIACENZA-Malattie Infettive, Italy.
⁷⁸ PISA-Malattie Infettive, Italy.
⁷⁹ PISA-Pediatria I Universita, Italy.
⁸⁰ PISA-Virologia, Italy.
⁸¹ PISTOIA-Malattie Infettive, Italy.
⁸² PRATO-Malattie Infettive, Italy.
⁸³ PRATO-Virologia, Italy.
⁸⁴ REGGIO EMILIA-Malattie Infettive, Italy.
⁸⁵ RIMINI-Malattie Infettive RIMINI, Italy.
⁸⁶ ROMA-Cattedra Malattie Infettive Tor Vergata, Italy.
⁸⁷ ROMA-Immunologia Clinica Umberto I, Italy.
⁸⁸ ROMA-Istituto Superiore di Sanita', Italy.
⁸⁹ ROMA-Istituto di Clinica Malattie Infettive Cattolica, Italy.
⁹⁰ ROMA-Malattie Infettive e Tropicali La Sapienza-Umberto I, Italy.
⁹¹ ROMA-Medicina Sperimentale e Patologia-Sezione Virologia-La Sapienza, Italy.
⁹² ROMA Virologia per Malattie Infettive Tor Vergata, Italy.
⁹³ ROMA, IRCCS Spallanzani, Italy.
⁹⁴ SAN REMO-Malattie Infettive, Italy.
⁹⁵ SIENA-Malattie Infettive, Italy.
⁹⁶ SIENA-Malattie Infettive 2, Italy.
⁹⁷ TERNI-Malattie Infettive, Italy.
⁹⁸ TORINO-Laboratorio di Virologia, Ospedale Amedeo di Savoia, Italy.
⁹⁹ TORINO-Malattie Infettive Amedeo di Savoia, Italy.
¹⁰⁰ TRENTO-Malattie Infettive, Italy.
¹⁰¹ TREVISO-Malattie Infettive, VERBANIA Malattie Infettive, Italy.
¹⁰² VERBANIA-Virologia, Italy.
¹⁰³ VERONA-Centro di Medicina Preventiva, Italy.
¹⁰⁴ VARESE-Clinica Malattie Infettive e Tropicali, Italy.
¹⁰⁵ VARESE-Virologia, Italy.
¹⁰⁶ VERBANIA-Malattie ULSS 20, Italy.

PMID: 31352080
DOI: 10.1016/j.cmi.2019.07.004

No abstract available

Publication types

Letter

MeSH terms

Adolescent
Adult
Anti-HIV Agents / therapeutic use
Drug Resistance, Viral / genetics*
Female
HIV Infections / drug therapy
HIV Infections / epidemiology
HIV Infections / transmission
HIV Infections / virology*
HIV-1 / drug effects
HIV-1 / genetics*
Humans
Infectious Disease Transmission, Vertical*
Italy / epidemiology
Male
Mutation
Prevalence
Retrospective Studies
Young Adult
pol Gene Products, Human Immunodeficiency Virus / genetics

Substances

Anti-HIV Agents
pol Gene Products, Human Immunodeficiency Virus