Two new alkaloids isolated from traditional Chinese medicine Binglang the fruit of Areca catechu

Abstract

Binglang, the fruit of Areca catechu L, has a long history as an important Chinese herbal medicine. Two new alkaloids (1 and 2), along with forty-one known compounds (3-43) were isolated from the dried fruit of Areca catechu L. The structures were elucidated on basis of the IR, UV, MS and 1D, 2D NMR spectroscopic data. Compounds 26 and 33 showed weak cytotoxicity against human gastric cancer cell line (BGC-823) with IC₅₀ of 15.91 μM and 20.13 μM, respectively.

Keywords: Alkaloids; Areca catechu; Arecaceae; Binglang; Structural identification; TCM.