MC4R and ENPP1 gene polymorphisms and their implication in maternal and neonatal risk for obesity

Claudiu Mărginean; Cristina Oana Mărginean; Mihaela Iancu; Lorena Elena Meliț; Florin Tripon; Claudia Bănescu

doi:10.1038/s41598-019-47402-2

MC4R and ENPP1 gene polymorphisms and their implication in maternal and neonatal risk for obesity

Sci Rep. 2019 Jul 26;9(1):10858. doi: 10.1038/s41598-019-47402-2.

Authors

Claudiu Mărginean¹, Cristina Oana Mărginean², Mihaela Iancu³, Lorena Elena Meliț¹, Florin Tripon⁴, Claudia Bănescu⁴

Affiliations

¹ Department of Obstetrics and Gynecology, University of Medicine, Pharmacy, Sciences and Technology, Târgu Mureș, Gheorghe Marinescu street no 38, Târgu Mureș, 540136, Romania.
² Department of Pediatrics, University of Medicine, Pharmacy, Sciences and Technology Târgu-Mureș, Gheorghe Marinescu street no 38, Târgu Mureș, 540136, Romania. marginean.oana@gmail.com.
³ Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy Cluj Napoca, Victor Babes street no 8, Cluj Napoca, Romania.
⁴ Genetics Laboratory, Center for Advanced Medical and Pharmaceutical Research, University of Medicine, Pharmacy, Sciences and Technology Târgu-Mures, Gheorghe Marinescu street no 38, Târgu Mureș, 540136, Romania.

Abstract

The aims of this study were to establish the role of MC4Rrs17782313 and ENPP1rs1044498 gene polymorphisms on pre-pregnancy BMI and the newborn's status. We performed a cross-sectional study on 185 mothers and their offspring. The groups were divided into: control group- underweight or normal mothers with BMI_initial < 25 kg/m² (n₁ = 134) and study group-overweight/obese mothers with BMI_initial ≥ 25 kg/m² (n₂ = 51). All subjects underwent demographic, anthropometric, paraclinical, bioimpedance and genetic parameters. We found association between initial BMI and gestational weight gain (GWG), and a higher frequency of excessive GWG in overweight/obese women (p = 0.037). Higher values of anthropometric and bioimpedance parameters were observed in overweight/obese versus underweight/normal women. The MC4R rs17782313 and ENPP1 rs1044498 variant genotypes had an increased risk of pre-pregnancy overweight (OR = 1.41; 95% CI:[0.72; 2.78]; OR = 1.34; 95% CI:[0.65; 2.75]). The newborns from mothers with excessive GWG had a higher birth weight (BW) (p = 0.001). Higher MUAC values were noticed in newborns with MC4R rs17782313 wild-type genotype. Also, BW was correlated with GWG status smoking in pregnancy, gestational age and neonatal ENPP1rs1044498 variant genotype (p = 0.026). Our study pointed out the role of MC4R rs17782313 and ENPP1 rs1044498 genotypes in obesity determinisms in mothers and their newborns in correlation with BMI, MUAC, TST and bioimpedance parameters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Arm
Birth Weight / genetics*
Body Mass Index
Body Size
Cross-Sectional Studies
Female
Genotype
Gestational Weight Gain / genetics*
Humans
Infant, Newborn
Obesity, Maternal / genetics*
Phosphoric Diester Hydrolases / genetics*
Polymorphism, Single Nucleotide*
Pregnancy
Pyrophosphatases / genetics*
Receptor, Melanocortin, Type 4 / genetics*
Risk Factors
Skinfold Thickness
Young Adult

Substances

MC4R protein, human
Receptor, Melanocortin, Type 4
Phosphoric Diester Hydrolases
ectonucleotide pyrophosphatase phosphodiesterase 1
Pyrophosphatases