Identifying, Characterizing, and Understanding Nefiracetam in Its Solid State Forms: A Potential Antidementia Drug

Abstract

In this work, 3 hitherto unidentified solid state forms of the nootropic drug Nefiracetam are identified: a monohydrate and 2 polymorphic phases of the anhydrate. These new forms were investigated from a structural and thermodynamic point of view to evaluate the possibility of using these forms in alternative formulations. Furthermore, their dissolution rate and solubility were compared.

Keywords: dissolution; formulation; hydrate; nefiracetam; polymorph; solid state.