Mesenchymal stem cells and IL-37: a powerful combination

A Gugliandolo; A L Caraffa; C E Gallenga; S K Kritas; G Ronconi; O Trubiani; P Conti; P Di Emidio; E Mazzon

Mesenchymal stem cells and IL-37: a powerful combination

J Biol Regul Homeost Agents. 2019 Jul-Aug;33(4):1019-1022.

Authors

A Gugliandolo¹, A L Caraffa², C E Gallenga³, S K Kritas⁴, G Ronconi⁵, O Trubiani⁶, P Conti⁷, P Di Emidio⁸, E Mazzon¹

Affiliations

¹ IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.
² School of Pharmacy, University of Camerino, Camerino, Italy.
³ Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Ferrara, Italy.
⁴ Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
⁵ Clinica dei Pazienti del Territorio, Fondazione Policlinico Gemelli, Rome, Italy.
⁶ Department of Oral and Biotechnology Medical Science, University of Chieti-Pescara, Chieti, Italy.
⁷ Postgraduate Medical School, University of Chieti, Chieti, Italy.
⁸ Maxillofacial Surgery "G. Mazzini" Hospital, Teramo, Italy.

PMID: 31347346

Abstract

Mesenchymal stem cells (MSCs) are able to exert immunomodulatory and anti-inflammatory actions. Thanks to these properties, MSCs may be a promising alternative approach for the treatment of inflammatory disease. Important cytokines involved in inflammation are those included in the IL-1 family. Interleukin-37 (IL-37) is one of the member able to suppress both innate and adaptive immunity. Recently, it was found that MSCs and their derivatives can modulate IL-37, and MSCs expressing IL-37 seem to have an enhanced therapeutic efficacy.

Keywords: IL-37; inflammation; mesenchymal stem cells.

Publication types

Editorial

MeSH terms

Cytokines
Humans
Inflammation
Interleukin-1 / physiology*
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / cytology*

Substances

Cytokines
IL37 protein, human
Interleukin-1