Charge-tuning of glycosaminoglycan-based hydrogels to program cytokine sequestration

Faraday Discuss. 2019 Oct 30;219(0):244-251. doi: 10.1039/c9fd00016j.

Abstract

Glycosaminoglycan (GAG)-based biohybrid hydrogels of varied GAG content and GAG sulfation pattern were prepared and applied to sequester cytokines. The binding of strongly acidic and basic cytokines correlated with the integral space charge density of the hydrogel, while the binding of weakly charged cytokines was governed by the GAG sulfation pattern.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Click Chemistry
  • Cytokines / chemistry*
  • Glycosaminoglycans / chemistry*
  • Heparin / chemistry
  • Humans
  • Hydrogels / chemistry*
  • Polyethylene Glycols / chemistry
  • Sulfates / chemistry
  • Sulfhydryl Compounds / chemistry

Substances

  • Cytokines
  • Glycosaminoglycans
  • Hydrogels
  • Sulfates
  • Sulfhydryl Compounds
  • Polyethylene Glycols
  • Heparin