15 N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging

Ivan V Skovpin; Alexandra Svyatova; Nikita Chukanov; Eduard Y Chekmenev; Kirill V Kovtunov; Igor V Koptyug

doi:10.1002/chem.201902724

¹⁵ N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging

Chemistry. 2019 Oct 1;25(55):12694-12697. doi: 10.1002/chem.201902724. Epub 2019 Sep 9.

Authors

Ivan V Skovpin^{1

2}, Alexandra Svyatova^{1

2}, Nikita Chukanov^{1

2}, Eduard Y Chekmenev^{3

4}, Kirill V Kovtunov^{1

2}, Igor V Koptyug^{1

2}

Affiliations

¹ International Tomography Center, SB RAS, 3A Institutskaya st., Novosibirsk, 630090, Russia.
² Novosibirsk State University, 2 Pirogova st., Novosibirsk, 630090, Russia.
³ Department of Chemistry, Karmanos Cancer Institute (KCI), Integrative Biosciences (Ibio), Wayne State University, Detroit, MI, USA.
⁴ Russian Academy of Sciences (RAS), 14 Leninskiy Prospekt, Moscow, 119991, Russia.

Abstract

Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize ¹⁵ N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire ¹⁵ N MR images at natural abundance of the ¹⁵ N nuclei for the first time.

Keywords: 15N natural abundance; MRI; SABRE; hyperpolarization; parahydrogen.

Abstract

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