Neurodevelopmental delay in normocephalic children with in utero exposure to Zika virus

Adriana Virginia Faiçal; Juliana Cabral de Oliveira; João Vitor Vieira Oliveira; Breno Lima de Almeida; Iluska Andrade Agra; Luiz Carlos Junior Alcantara; Angelina Xavier Acosta; Isadora Cristina de Siqueira

doi:10.1136/bmjpo-2019-000486

Neurodevelopmental delay in normocephalic children with in utero exposure to Zika virus

BMJ Paediatr Open. 2019 Jul 5;3(1):e000486. doi: 10.1136/bmjpo-2019-000486. eCollection 2019.

Authors

Adriana Virginia Faiçal¹, Juliana Cabral de Oliveira², João Vitor Vieira Oliveira², Breno Lima de Almeida², Iluska Andrade Agra¹, Luiz Carlos Junior Alcantara², Angelina Xavier Acosta^#¹, Isadora Cristina de Siqueira^#²

Affiliations

¹ School of Medicine - Department of Pediatrics, Federal University of Bahia, Salvador, Bahia, Brazil.
² Gonçalo Moniz Institute, Oswaldo Cruz Fundation, Salvador, Bahia, Brazil.

^# Contributed equally.

Abstract

Neurodevelopment in 29 normocephalic children with in utero exposure to Zika virus (ZIKV) was evaluated by the Bayley Scales of Infant and Toddler Development-Third Edition. Ten (35%) infants presented neurodevelopment delay. Language, cognitive and motor delays were identified in 9 (31%), 4 (14%) and 1 (3%) infants, respectively. Children exposed to ZIKV in utero must undergo careful evaluations for the early detection of any neurodevelopment delays in order to implement prompt intervention.

Keywords: Bayley-III; Zika virus; congenital infection; neurodevelopment.