Complete Nucleotide Sequences of mcr-4.3-Carrying Plasmids in Acinetobacter baumannii Sequence Type 345 of Human and Food Origin from the Czech Republic, the First Case in Europe

Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01166-19. doi: 10.1128/AAC.01166-19. Print 2019 Oct.

Abstract

Here, we describe two plasmids carrying mcr-4.3 in two Acinetobacter baumannii strains isolated from imported food and a clinical sample. The comparative analysis of these plasmids, with two other plasmids reported in the NCBI database, highlighted the common origin of the plasmidic structure carrying mcr-4.3 This is the first case of the mcr-4.3 gene in a A. baumannii strain isolated from a clinical case in Europe. We hypothesize that food import is initiating the spread in Czech Republic.

Keywords: Acinetobacter baumannii; WGS; colistin resistance; mcr-4.3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter baumannii / genetics*
  • Aged, 80 and over
  • Czech Republic
  • Drug Resistance, Bacterial / genetics
  • Europe
  • Female
  • Humans
  • Microbial Sensitivity Tests
  • Peptides / genetics
  • Plasmids / genetics*

Substances

  • Peptides