The management and referral of iliofemoral deep venous thrombosis in North West London

J Vasc Surg Venous Lymphat Disord. 2020 Mar;8(2):182-186. doi: 10.1016/j.jvsv.2019.04.011. Epub 2019 Jul 18.

Abstract

Background: Post-thrombotic syndrome is a common complication of iliofemoral deep venous thrombosis (IFDVT). Existing evidence and National Institute for Health and Care Excellence guidelines suggest that this can be reduced by prompt thrombolytic therapy or thrombectomy. We aimed to evaluate the characteristics of IFDVT patients and to identify whether patients are being offered the recommended treatment pathway.

Methods: A multicenter cross-sectional study was conducted across eight hospital sites in the North West London region, of which two were hub hospitals in their local vascular service networks. Patients with proximal DVT were identified using International Classification of Diseases, Tenth Revision coding during a 1-year period. Data on demographics, diagnostic methods used, interventions, and referrals were extracted from electronic and paper medical records.

Results: During the study period, 132 patients with IFDVT were identified (mean age, 59.4 years; 55% female); 75% of these patients had an IFDVT. In this cohort, the biggest predisposing factors were previous DVT (n = 35), malignant disease (n = 35), and immobility (n = 20). In total, 104 patients were administered anticoagulation, and 88 of these patients received anticoagulation within 24 hours. The cases of 45 patients were either discussed with or promptly referred to a vascular service, after which 20 patients were treated solely with anticoagulation, whereas 20 patients received thrombolysis of varying methods.

Conclusions: A significant proportion (56%) of symptomatic IFDVT patients are not being appropriately referred to or discussed with vascular services. Of these, 43% would have been eligible for consideration of early thrombus removal. Adherence to the National Institute for Health and Care Excellence guidelines could be improved by increasing awareness among emergency department colleagues.

Keywords: Iliofemoral deep vein thrombosis; Post-thrombotic syndrome; Thrombolysis.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anticoagulants / adverse effects
  • Anticoagulants / therapeutic use*
  • Cross-Sectional Studies
  • Female
  • Femoral Vein* / diagnostic imaging
  • Guideline Adherence
  • Humans
  • Iliac Vein* / diagnostic imaging
  • London
  • Male
  • Middle Aged
  • Postthrombotic Syndrome / etiology
  • Postthrombotic Syndrome / prevention & control
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians'*
  • Referral and Consultation*
  • Thrombolytic Therapy* / adverse effects
  • Time Factors
  • Treatment Outcome
  • Venous Thrombosis / complications
  • Venous Thrombosis / diagnostic imaging
  • Venous Thrombosis / therapy*

Substances

  • Anticoagulants