Fatal hemolytic disease of the fetus and newborn caused by anti-Jra antibody: A case report and literature review

Abstract

The Jr^a antigen of the JR blood group system is a highly prevalent red blood cell antigen. Although anti-Jr^a-associated hemolytic disease of the fetus and newborn (HDFN) is generally considered mild-to-moderate, a rare fatal case was recently reported. We report the third example of HDFN-related anti-Jr^a with fatal outcomes. The clinical significance of anti-Jr^a antibody as a cause of HDFN should be reassessed.

Keywords: ABCG2; Anti-Jr(a); Fatality; Hemolytic disease of the fetus and newborn.