De novo generation of a functional human thymus from induced pluripotent stem cells

J Allergy Clin Immunol. 2019 Nov;144(5):1416-1419.e7. doi: 10.1016/j.jaci.2019.05.042. Epub 2019 Jul 16.

Affiliations

¹ Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
² Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands.
³ Department of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands.
⁴ LUMC Animal Facility, Leiden University Medical Center, Leiden, the Netherlands.
⁵ Department of Cell & Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
⁶ Department of Cell & Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands; LUMC hiPSC Hotel, Leiden University Medical Center, Leiden, the Netherlands.
⁷ Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: f.j.t.staal@lumc.nl.

PMID: 31323248
DOI: 10.1016/j.jaci.2019.05.042

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation
Cells, Cultured
Forkhead Transcription Factors / genetics
Humans
Induced Pluripotent Stem Cells / physiology*
Mice
Mice, Knockout
Mice, Nude
Morphogenesis
Organ Culture Techniques
Organ Transplantation
Thymus Gland / physiology*
Thymus Gland / transplantation
Transplantation, Heterologous

Substances

Forkhead Transcription Factors
Whn protein