Cancer chemotherapy drug wastage in a tertiary care hospital in India-A 3-month prospective and 1-year retrospective study

Br J Clin Pharmacol. 2019 Oct;85(10):2428-2435. doi: 10.1111/bcp.14064. Epub 2019 Aug 1.

Abstract

This study prospectively quantified wastage of cancer chemotherapeutic drugs in an oncology unit to find the associated cost in 3 months. Retrospective analysis of drug usage for 12 months was also conducted to determine the expected drug loss in 1 year. The effect of vial sharing was evaluated under the assumption of sharing. A significant drug wastage of 19.72% (95% confidence interval [CI], 14.52-24.93%) in 3 months and 17.14% (95% CI 14.69-19.59%) in 1 year occurred in our oncology unit. Number of vials purchased (r = 0.362, p < 0.01), weight (r = -0.146, P < .01) and body surface area (r = -0.26, P < .01) correlated with the drug wasted. Vial sharing assumption showed a 9% (95% CI, 2.5-15.5%) reduction in cost in 1 year.

Keywords: Cancer; chemotherapy; health economics; health services research; oncology.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / economics
  • Body Surface Area
  • Drug Costs / statistics & numerical data
  • Female
  • Humans
  • India
  • Male
  • Middle Aged
  • Neoplasms / drug therapy*
  • Neoplasms / economics
  • Prospective Studies
  • Retrospective Studies
  • Tertiary Care Centers
  • Waste Products / economics
  • Waste Products / statistics & numerical data*

Substances

  • Antineoplastic Agents
  • Waste Products