Looking for safety but overlooking efficacy: Non-inferiority trials of anti-diabetics

Eur J Intern Med. 2019 Sep:67:e9-e10. doi: 10.1016/j.ejim.2019.07.006. Epub 2019 Jul 16.

Authors

Vittorio Bertele'¹, Rita Banzi², Chiara Gerardi², Silvio Garattini²

Affiliations

¹ Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy. Electronic address: vittorio.bertele@marionegri.it.
² Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.

PMID: 31320152
DOI: 10.1016/j.ejim.2019.07.006

No abstract available

Keywords: Anti-diabetic medicines; Diabetes; Glycemic control; Hypoglycemic drugs; Non-inferiority trials; Placebo; Randomized clinical trials.

Publication types

Letter

MeSH terms

Equivalence Trials as Topic*
Humans
Hypoglycemic Agents / adverse effects
Hypoglycemic Agents / therapeutic use*
Treatment Outcome

Substances

Hypoglycemic Agents