Data for isolation and properties analysis of diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide

Alexander A Lomzov; Maxim S Kupryushkin; Andrey V Shernyukov; Mikhail D Nekrasov; Ilya S Dovydenko; Dmitry A Stetsenko; Dmitrii V Pyshnyi

doi:10.1016/j.dib.2019.104148

Data for isolation and properties analysis of diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide

Data Brief. 2019 Jun 20:25:104148. doi: 10.1016/j.dib.2019.104148. eCollection 2019 Aug.

Authors

Alexander A Lomzov^{1

2}, Maxim S Kupryushkin¹, Andrey V Shernyukov^{3

2}, Mikhail D Nekrasov¹, Ilya S Dovydenko¹, Dmitry A Stetsenko^{1

2}, Dmitrii V Pyshnyi^{1

2}

Affiliations

¹ Institute of Chemical Biology and Fundamental Medicine, SB RAS, 8 Lavrentiev Avenue, Novosibirsk, 630090, Russia.
² Novosibirsk State University, 2 Pirogova St., Novosibirsk 630090, Russia.
³ N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9 Lavrentiev Avenue, Novosibirsk, 630090, Russia.

Abstract

This article presents new data on the properties of the diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotides d(TpCp*A) [1,2]. The data include information on isolation, identification, treatment with snake venom phosphodiesterase and structural analysis by 1D and 2D NMR spectroscopy and restrained molecular dynamics analysis. The data can be used for preparation, analysis, application of phosphoryl guanidine oligonucleotide and for development of new nucleic acids derivatives. This data article is associated with the manuscript titled "Diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide: isolation and properties" [1].

Keywords: Circular dichroism; Diastereomer assignment phosphodiesterase digestion assay; Molecular dynamics; NMR; Phosphoryl guanidine oligonucleotide; RP-HPLC; Spatial structure.