Fetal hemoglobin does not inhibit Plasmodium falciparum growth

Blood Adv. 2019 Jul 23;3(14):2149-2152. doi: 10.1182/bloodadvances.2019000399.

Authors

Natasha M Archer^{1

2}, Nicole Petersen^{1

2}, Manoj T Duraisingh²

Affiliations

¹ Pediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA; and.
² Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA.

Abstract

P falciparum growth is not inhibited in either cord or heterozygote hereditary persistence of fetal hemoglobin erythrocytes.
P falciparum growth in fetal hemoglobin erythrocytes is oxygen independent.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Erythrocytes / metabolism
Erythrocytes / parasitology
Erythrocytes / pathology
Fetal Hemoglobin / metabolism*
Histocytochemistry
Humans
Life Cycle Stages
Malaria, Falciparum / blood
Malaria, Falciparum / metabolism*
Malaria, Falciparum / parasitology*
Plasmodium falciparum / growth & development*

Substances

Fetal Hemoglobin

Grants and funding