HIV, immune activation and salt-sensitive hypertension (HISH): a research proposal

BMC Res Notes. 2019 Jul 16;12(1):424. doi: 10.1186/s13104-019-4470-2.

Abstract

Objective: The objective of this study is to quantify and compare the effect of excess dietary salt on immune cell activation and blood pressure in HIV versus HIV negative individuals.

Results: Salt-sensitivity is associated with increased immune cell activation in animal studies. This concept has not been tested in people living with HIV. This study will therefore add more information in elucidating the interaction between HIV infection and/or anti-retroviral therapy (ART), immune-activation/inflammation and hypertension.

Keywords: HIV; Hypertension; Immune activation; Salt-sensitivity.

MeSH terms

  • Adult
  • Anti-Retroviral Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / physiopathology
  • HIV Infections / virology
  • Humans
  • Hypertension / etiology
  • Hypertension / physiopathology*
  • Immune System / cytology
  • Immune System / drug effects
  • Immune System / immunology*
  • Male
  • Prospective Studies
  • Research Design
  • Sodium Chloride, Dietary / administration & dosage*
  • Sodium Chloride, Dietary / adverse effects
  • Young Adult
  • Zambia

Substances

  • Anti-Retroviral Agents
  • Sodium Chloride, Dietary