Safety and Tolerability of Clofazimine in a Cohort of Children With Odontogenic Mycobacterium abscessus Infection

J Pediatric Infect Dis Soc. 2020 Sep 17;9(4):483-485. doi: 10.1093/jpids/piz049.

Abstract

Mycobacterium abscessus infections can be challenging to treat. Clofazimine has excellent in vitro activity against M abscessus, but reports of its use, particularly in children, have been limited. In this study, clofazimine was given to 27 children during an outbreak of odontogenic mycobacterial infections and seemed to be well tolerated as part of a multidrug regimen.

Keywords: child; clofazimine; disease outbreaks; nontuberculous mycobacteria; odontogenic infection.

MeSH terms

  • California / epidemiology
  • Child
  • Child, Preschool
  • Clofazimine / adverse effects
  • Clofazimine / therapeutic use*
  • Cross Infection / drug therapy*
  • Cross Infection / epidemiology
  • Cross Infection / microbiology*
  • Dental Offices
  • Disease Outbreaks
  • Female
  • Focal Infection, Dental / drug therapy*
  • Focal Infection, Dental / epidemiology
  • Focal Infection, Dental / microbiology*
  • Humans
  • Male
  • Mycobacterium Infections, Nontuberculous / drug therapy*
  • Mycobacterium Infections, Nontuberculous / epidemiology
  • Patient Safety

Substances

  • Clofazimine