Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis

Ke Jin; Shufei Wang; Yazhuo Zhang; Mengfang Xia; Yongzhen Mo; Xiaoling Li; Guiyuan Li; Zhaoyang Zeng; Wei Xiong; Yi He

doi:10.1007/s00018-019-03222-1

Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis

Cell Mol Life Sci. 2019 Nov;76(21):4275-4289. doi: 10.1007/s00018-019-03222-1. Epub 2019 Jul 15.

Authors

Ke Jin^{1

2

3}, Shufei Wang², Yazhuo Zhang², Mengfang Xia², Yongzhen Mo², Xiaoling Li^{1

2

3}, Guiyuan Li^{1

2

3}, Zhaoyang Zeng^{1

2

3}, Wei Xiong^{4

5

6}, Yi He^{7

8}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis (Central South University) and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ NHC Key Laboratory of Carcinogenesis (Central South University) and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁵ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁶ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁷ NHC Key Laboratory of Carcinogenesis (Central South University) and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. yihe@csu.edu.cn.
⁸ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. yihe@csu.edu.cn.

Abstract

Numerous studies have shown that non-coding RNAs play crucial roles in the development and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on chromosome 8q24.21, which constitutes a fragile site for genetic aberrations. PVT1 is well-known for its interaction with its neighbor MYC, which is a qualified oncogene that plays a vital role in tumorigenesis. In the past several decades, increasing attention has been paid to the interaction mechanism between PVT1 and MYC, which will benefit the clinical treatment and prognosis of patients. In this review, we summarize the coamplification of PVT1 and MYC in cancer, the positive feedback mechanism, and the latest promoter competition mechanism of PVT1 and MYC, as well as how PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules. We also briefly describe the treatment prospects and research directions of PVT1 and MYC.

Keywords: Enhancer; Gene fusion; MYC; PVT1; Positive feedback; Promoter.

Publication types

Review

MeSH terms

Carcinogenesis / genetics*
Carcinogenesis / metabolism
Carcinogenesis / pathology
Gene Expression Regulation, Neoplastic
Humans
Oncogenes
Protein Binding / physiology
Proto-Oncogene Proteins c-myc / metabolism*
RNA, Long Noncoding / metabolism*
Signal Transduction / genetics

Substances

MYC protein, human
PVT1 long-non-coding RNA, human
Proto-Oncogene Proteins c-myc
RNA, Long Noncoding

Abstract

Publication types

MeSH terms

Substances

Grants and funding