Abstract
α4β1 integrin and VEGFR2 function as a receptor complex for VEGF in CLL cells.
Contribution to VEGF functions in CLL is a novel pathological role for α4β1 integrin in this malignancy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Humans
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Integrin alpha4beta1 / metabolism*
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Intracellular Space / metabolism
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Leukemia, Lymphocytic, Chronic, B-Cell / etiology
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Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Protein Binding
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Signal Transduction*
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Vascular Endothelial Growth Factor A / metabolism*
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Vascular Endothelial Growth Factor Receptor-2 / metabolism*
Substances
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Integrin alpha4beta1
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factor Receptor-2