Abstract
Three new pyranoxanthones, calotetrapterins A-C (1-3) were isolated from the stem bark of Calophyllum tetrapterum Miq along with three known xanthones, α-mangostin (4), garciniafuran (5), and pyranojacareubin (6). All structures were elucidated based on their IR, UV, HRESIMS, 1 D (1H, 13C) and 2 D (HMBC, HMQC) NMR spectral data. Compounds 1-6 were tested to P-388 cells for cytotoxic activity, compound 2 exhibited high activity with IC50 value 1.0 μM.
Keywords:
Calophyllum tetrapterum; Calotetrapterins A-C; P-388 cell; pyranoxanthone.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Calophyllum / chemistry*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Leukemia / drug therapy
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Leukemia / pathology
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Plant Bark / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Structure-Activity Relationship
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Xanthones / chemistry*
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Xanthones / isolation & purification
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Xanthones / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Xanthones
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mangostin