Non-Coding RNAs and their Integrated Networks

J Integr Bioinform. 2019 Jul 13;16(3):20190027. doi: 10.1515/jib-2019-0027.

Abstract

Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are different types of non-coding RNAs that modulate complex molecular and cellular processes. RNA sequencing technologies and bioinformatics methods greatly promoted the study of ncRNAs, which revealed ncRNAs' essential roles in diverse aspects of biological functions. As important key players in gene regulatory networks, ncRNAs work with other biomolecules, including coding and non-coding RNAs, DNAs and proteins. In this review, we discuss the distinct types of ncRNAs, including housekeeping ncRNAs and regulatory ncRNAs, their versatile functions and interactions, transcription, translation, and modification. Moreover, we summarize the integrated networks of ncRNA interactions, providing a comprehensive landscape of ncRNAs regulatory roles.

Keywords: ceRNA network; integrated network; ncRNA interaction; non-coding RNA; regulatory ncRNA.

Publication types

  • Review

MeSH terms

  • Computational Biology*
  • Gene Regulatory Networks*
  • RNA, Untranslated* / genetics
  • RNA, Untranslated* / metabolism
  • Sequence Analysis, RNA*

Substances

  • RNA, Untranslated

Grants and funding

This work has been supported by the National Key Research and Development Program of China (Grant Nos. 2018YFC0310602 and 2016YFA0501704), National Natural Science Foundation of China (Funder Id: Funder Id: http://dx.doi.org/10.13039/501100001809, Grant Nos. 31771477 and 31571366), the Fundamental Research Funds for the Central Universities, Jiangsu Collaborative Innovation Center for Modern Crop Production and 2018 Zhejiang University Academic Award for Outstanding Doctoral Candidates.