Selective targeting of DC-SIGN by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold

Hsin-Chuan Wen; Cin-Hao Lin; Jen-Sheng Huang; Chia-Lung Tsai; Ting-Feng Chen; Sheng-Kai Wang

doi:10.1039/c9cc03124c

Selective targeting of DC-SIGN by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold

Chem Commun (Camb). 2019 Jul 30;55(62):9124-9127. doi: 10.1039/c9cc03124c.

Authors

Hsin-Chuan Wen¹, Cin-Hao Lin, Jen-Sheng Huang, Chia-Lung Tsai, Ting-Feng Chen, Sheng-Kai Wang

Affiliation

¹ Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan. skwang@mx.nthu.edu.tw.

PMID: 31298664
DOI: 10.1039/c9cc03124c

Abstract

DC-SIGN and langerin receptors both bind to oligomannose but lead to opposite effects upon encountering HIV. Because selective targeting of DC-SIGN can lead to anti-viral effects, we developed a glycoconjugate, which provides over 4800-fold selectivity for DC-SIGN over langerin, by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold.