Imaging biomarkers for the treatment of esophageal cancer

World J Gastroenterol. 2019 Jun 28;25(24):3021-3029. doi: 10.3748/wjg.v25.i24.3021.

Abstract

Esophageal cancer is known as one of the malignant cancers with poor prognosis. To improve the outcome, combined multimodality treatment is attempted. On the other hand, advances in genomics and other "omic" technologies are paving way to the patient-oriented treatment called "personalized" or "precision" medicine. Recent advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis, treatment response, and prognosis in cancer treatment. In this review, we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer.

Keywords: Computed tomography perfusion; Diffusion-weighted imaging; Dynamic-contrast-enhanced magnetic resonance imaging; Esophageal cancer; Positron emission tomography; Texture analysis.

Publication types

  • Review

MeSH terms

  • Chemoradiotherapy, Adjuvant*
  • Diffusion Magnetic Resonance Imaging
  • Esophageal Neoplasms / diagnostic imaging
  • Esophageal Neoplasms / genetics
  • Esophageal Neoplasms / therapy*
  • Esophagectomy*
  • Esophagus / diagnostic imaging*
  • Esophagus / pathology
  • Humans
  • Perfusion Imaging
  • Positron-Emission Tomography
  • Precision Medicine / methods*
  • Precision Medicine / trends
  • Prognosis
  • Tomography, X-Ray Computed
  • Treatment Outcome