Whole genome sequence of first Candida auris strain, isolated in Russia

Med Mycol. 2020 Apr 1;58(3):414-416. doi: 10.1093/mmy/myz078.

Abstract

Candida auris is an emergent yeast pathogen, easily transmissible between patients and with high percent of multidrug resistant strains. Here we present a draft genome sequence of the first known Russian strain of C. auris, isolated from a case of candidemia. The strain clustered within South Asian C. auris clade and seemingly represented an independent event of dissemination from the original species range. Observed fluconazole resistance was probably due to F105L and K143R mutations in ERG11.

Keywords: Candida auris; Russia; candidemia; drug resistance; whole genome sequencing.

MeSH terms

  • Antifungal Agents / pharmacology
  • Candida / drug effects
  • Candida / genetics*
  • Candida / isolation & purification
  • Candidemia / microbiology
  • Drug Resistance, Fungal / genetics*
  • Fluconazole / pharmacology
  • Genome, Fungal*
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Phylogeny
  • Russia
  • Whole Genome Sequencing

Substances

  • Antifungal Agents
  • Fluconazole