Clearing debris

Nat Chem Biol. 2019 Aug;15(8):760-761. doi: 10.1038/s41589-019-0320-8.

Abstract

A new small molecule that targets the vacuolar H+-ATPase activates autophagy, inhibits mTORC1 signaling, and displays potential for clearing toxic protein aggregates involved in neurodegenerative diseases.

MeSH terms

  • Animals
  • Autophagy / drug effects*
  • Mechanistic Target of Rapamycin Complex 1 / antagonists & inhibitors*
  • Neurodegenerative Diseases
  • Protein Aggregates
  • Proton-Translocating ATPases / metabolism*
  • Pyrazoles / pharmacology
  • Signal Transduction

Substances

  • Protein Aggregates
  • Pyrazoles
  • autophagy activator EN6
  • Mechanistic Target of Rapamycin Complex 1
  • Proton-Translocating ATPases