Abstract
A new small molecule that targets the vacuolar H+-ATPase activates autophagy, inhibits mTORC1 signaling, and displays potential for clearing toxic protein aggregates involved in neurodegenerative diseases.
MeSH terms
-
Animals
-
Autophagy / drug effects*
-
Mechanistic Target of Rapamycin Complex 1 / antagonists & inhibitors*
-
Neurodegenerative Diseases
-
Protein Aggregates
-
Proton-Translocating ATPases / metabolism*
-
Pyrazoles / pharmacology
-
Signal Transduction
Substances
-
Protein Aggregates
-
Pyrazoles
-
autophagy activator EN6
-
Mechanistic Target of Rapamycin Complex 1
-
Proton-Translocating ATPases