Impact of vaccination on antibiotic usage: a systematic review and meta-analysis

B S Buckley; N Henschke; H Bergman; B Skidmore; E J Klemm; G Villanueva; C Garritty; M Paul

doi:10.1016/j.cmi.2019.06.030

Impact of vaccination on antibiotic usage: a systematic review and meta-analysis

Clin Microbiol Infect. 2019 Oct;25(10):1213-1225. doi: 10.1016/j.cmi.2019.06.030. Epub 2019 Jul 5.

Authors

B S Buckley¹, N Henschke², H Bergman³, B Skidmore⁴, E J Klemm⁵, G Villanueva³, C Garritty⁶, M Paul⁷

Affiliations

¹ Department of Surgery, University of the Philippines Manila, Philippine General Hospital, Manila, Philippines; Cochrane Response, Cochrane, London, UK.
² Cochrane Response, Cochrane, London, UK. Electronic address: nhenschke@cochrane.org.
³ Cochrane Response, Cochrane, London, UK.
⁴ Independent Information Specialist, Ottawa, ON, Canada.
⁵ Wellcome Trust, London, UK.
⁶ Knowledge Synthesis Group, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
⁷ Institute of Infectious Diseases, Rambam Health Care Campus, Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

PMID: 31284031
DOI: 10.1016/j.cmi.2019.06.030

Abstract

Background: Vaccines may reduce antibiotic use and the development of resistance.

Objectives: To provide a comprehensive, up-to-date assessment of the evidence base relating to the effect of vaccines on antibiotic use.

Data sources: Ovid MEDLINE, Embase, the Cochrane Library, ClinicalTrials.gov and WHO Trials Registry.

Study eligibility criteria: Randomized controlled trials (RCTs) and observational studies published from January 1998 to March 2018.

Participants: Any population.

Interventions: Vaccines versus placebo, no vaccine or another vaccine.

Methods: Titles, abstracts and full-texts were screened independently by two reviewers. Certainty of RCT evidence was assessed using GRADE.

Results: In all, 4980 records identified; 895 full-text reports assessed; 96 studies included (24 RCTs, 72 observational). There was high-certainty evidence that influenza vaccine reduces days of antibiotic use among healthy adults (one RCT; n = 4253; rate reduction 28·1%; 95% CI 16·0-38·4); moderate-certainty evidence that influenza vaccines probably reduce antibiotic use in children aged 6 months to 14 years (three RCTs; n = 610; ratio of means 0·62; 95% CI 0·54-0·70) and probably reduce community antibiotic use in children aged 3-15 years (one RCT; n = 10 985 person-seasons; risk ratio 0·69, 95% CI 0·58-0·83); and moderate-certainty evidence that pneumococcal vaccination probably reduces antibiotic use in children aged 6 weeks to 6 years (two RCTs; n = 47 945; rate ratio 0·93, 95% CI 0·87-0·99) and reduces illness episodes requiring antibiotics in children aged 12-35 months (one RCT; n = 264; rate ratio 0·85, 95% CI 0·75-0·97). Other RCT evidence was of low or very low certainty, and observational evidence was affected by confounding.

Conclusions: The evidence base is poor. Although some vaccines may reduce antibiotic use, collection of high-quality data in future vaccine trials is needed to improve the evidence base.

Prospero registration: CRD42018103881.

Keywords: Antibiotic; Global health; Meta analysis; Systematic review; Vaccine.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Child
Child, Preschool
Drug Utilization / statistics & numerical data*
Female
Global Health
Humans
Infant
Infant, Newborn
Male
Middle Aged
Observational Studies as Topic
Randomized Controlled Trials as Topic
Vaccination / statistics & numerical data*
Young Adult

Substances

Anti-Bacterial Agents