The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS)

PLoS One. 2019 Jul 8;14(7):e0219379. doi: 10.1371/journal.pone.0219379. eCollection 2019.

Abstract

Background: Prenatal psychological stress may increase the risk of placental abruption (PA). This study aimed to clarify the effects of psychological distress during pregnancy and exposure to stressful life events in the year before or during pregnancy on the occurrence of PA in Japanese women.

Methods: Using a nationwide prospective birth cohort study, we obtained data from 103,099 women between January 2011 and March 2014. Information on exposure to 14 stressful life events and psychological distress (Kessler 6 scale) was collected using a self-administered questionnaire during pregnancy. Clinical diagnoses of PA were obtained from medical records. A total of 80,799 women with singleton births were analyzed using logistic regression models that adjusted for possible confounders.

Results: PA was diagnosed in 335 (0.4%) women. There was no significant difference in the Kessler 6 score during pregnancy between the PA group and non-PA group. Exposure to the death of a child in the year before or during pregnancy was significantly associated with PA in multigravid women (adjusted odds ratio [aOR] 3.57; 95% confidence interval [CI] 1.50-8.34). A spouse's loss of employment was significantly associated with PA in parous women (aOR 3.25; 95% CI 1.40-7.56).

Conclusions: This study identified the possible effects of exposure to the death of a child on PA occurrence that adjusted for important confounding factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abruptio Placentae / diagnosis*
  • Abruptio Placentae / epidemiology
  • Abruptio Placentae / etiology
  • Adult
  • Child
  • Female
  • Humans
  • Japan / epidemiology
  • Logistic Models
  • Odds Ratio
  • Pregnancy
  • Prospective Studies
  • Risk Factors
  • Stress Disorders, Traumatic / complications
  • Stress Disorders, Traumatic / pathology*
  • Stress, Psychological
  • Young Adult

Grants and funding

The Japan Environment and Children’s Study was funded by the Ministry of the Environment, the Government of Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.