Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

Jing Hu; Jie Jiao; Ying Wang; Mingyan Gao; Zhengcheng Lu; Fan Yang; Cuihua Hu; Zhengxun Song; Yujuan Chen; Zuobin Wang

doi:10.1016/j.micron.2019.102710

Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

Micron. 2019 Sep:124:102710. doi: 10.1016/j.micron.2019.102710. Epub 2019 Jul 2.

Authors

Jing Hu¹, Jie Jiao², Ying Wang¹, Mingyan Gao¹, Zhengcheng Lu³, Fan Yang¹, Cuihua Hu¹, Zhengxun Song¹, Yujuan Chen⁴, Zuobin Wang⁵

Affiliations

¹ Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China.
² Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; School of Life Sciences, Changchun University of Science and Technology, Changchun 130022, China.
³ JR3CN & IRAC, University of Bedfordshire, Luton LU1 3JU, UK.
⁴ Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; School of Life Sciences, Changchun University of Science and Technology, Changchun 130022, China. Electronic address: chenyujuan@cust.edu.cn.
⁵ Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; JR3CN & IRAC, University of Bedfordshire, Luton LU1 3JU, UK. Electronic address: wangz@cust.edu.cn.

PMID: 31280008
DOI: 10.1016/j.micron.2019.102710

Abstract

Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.

Keywords: Anti-tumor effect; Ginseng-extracted compounds; Hepatocelluar carcinoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Carcinoma, Hepatocellular / drug therapy
Carcinoma, Hepatocellular / pathology*
Cell Membrane / drug effects
Drug Discovery
Hep G2 Cells
Humans
Liver Neoplasms / drug therapy
Liver Neoplasms / pathology*
Panax / chemistry*
Plant Extracts / pharmacology*

Substances

Antineoplastic Agents
Plant Extracts