Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases

Biomaterials. 2019 Oct:217:119292. doi: 10.1016/j.biomaterials.2019.119292. Epub 2019 Jun 21.

Abstract

Neurodegenerative diseases and disorders seriously impact memory and cognition and can become life-threatening. Current medical techniques attempt to combat these detrimental effects mainly through the administration of neuromedicine. However, drug efficacy is limited by rapid dispersal of the drugs to off-target sites while the site of administration is prone to overdose. Many neuropathological conditions are accompanied by excessive reactive oxygen species (ROS) due to the inflammatory response. Accordingly, ROS-responsive drug delivery systems have emerged as a promising solution. To guide intelligent and comprehensive design of ROS-responsive drug delivery systems, this review article discusses the two following topics: (1) the biology of ROS in both healthy and diseased nervous systems and (2) recent developments in ROS-responsive, drug delivery system design. Overall, this review article would assist efforts to make better decisions about designing ROS-responsive, neural drug delivery systems, including the selection of ROS-responsive functional groups.

Keywords: Drug delivery; Neuroinflammation; Neurological disorders; Reactive oxygen species.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems
  • Humans
  • Nervous System / metabolism
  • Neurodegenerative Diseases / metabolism*
  • Reactive Oxygen Species / metabolism*

Substances

  • Reactive Oxygen Species