For many years, plants are used for treatment of various diseases. In general, plants have rather more therapeutic benefits and fewer adverse effects compared with the synthetic drugs. The purpose of this study was to determine the in vitro antimicrobial potentials of fifteen plant species from Anatolia region of Turkey against some selected bacteria and a yeast strain. The extracts from belong to nine families were examined against Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 43300 (MRSA), Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231 using disc diffusion and micro dilution methods. According to the obtained results, all plant extracts showed different ranges of antibacterial activity against S. aureus ATCC 43300 and S. aureus ATCC 25923 strains. Flower and leaves extracts of R. lutea, leaves extract of E. ritro, flower and leaves extracts of H. europaeum, leaves extract of E. macroclada, fruit and leaves extracts of Z. fabago, flower extract of C.crupinastrum, leaves extract of D. tenuifolia showed different ranges of antifungal activity against C. albicans.