Abstract
• Molecular intervertebral disc damage was associated with LBP and radiculopathy.• Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.• GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Biomarkers / analysis
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Female
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Glycosaminoglycans / metabolism
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Humans
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Intervertebral Disc / diagnostic imaging*
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Intervertebral Disc / metabolism
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Intervertebral Disc Degeneration / complications
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Intervertebral Disc Degeneration / diagnostic imaging*
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Intervertebral Disc Degeneration / metabolism
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Low Back Pain / etiology
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Low Back Pain / metabolism
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Low Back Pain / physiopathology*
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Lumbar Vertebrae / metabolism
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Lumbar Vertebrae / physiopathology
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Magnetic Resonance Imaging / methods*
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Male
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Middle Aged
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Prospective Studies
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Radiculopathy / etiology
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Radiculopathy / metabolism
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Radiculopathy / physiopathology*
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Young Adult
Substances
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Biomarkers
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Glycosaminoglycans