MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy

Eur Radiol. 2019 Dec;29(12):6443-6446. doi: 10.1007/s00330-019-06305-6. Epub 2019 Jul 5.

Abstract

• Molecular intervertebral disc damage was associated with LBP and radiculopathy.• Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.• GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / analysis
  • Female
  • Glycosaminoglycans / metabolism
  • Humans
  • Intervertebral Disc / diagnostic imaging*
  • Intervertebral Disc / metabolism
  • Intervertebral Disc Degeneration / complications
  • Intervertebral Disc Degeneration / diagnostic imaging*
  • Intervertebral Disc Degeneration / metabolism
  • Low Back Pain / etiology
  • Low Back Pain / metabolism
  • Low Back Pain / physiopathology*
  • Lumbar Vertebrae / metabolism
  • Lumbar Vertebrae / physiopathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Prospective Studies
  • Radiculopathy / etiology
  • Radiculopathy / metabolism
  • Radiculopathy / physiopathology*
  • Young Adult

Substances

  • Biomarkers
  • Glycosaminoglycans