Association between serum vitamin B6 concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study

Jing Wang; Lin Chen; Yan Zhang; Chen-Guang Li; Hao Zhang; Qiang Wang; Xiaofeng Qi; Liang Qiao; Wei-Wei Da; Xue-Jun Cui; Sheng Lu; Yong-Jun Wang; Bing Shu

doi:10.1136/bmjopen-2018-028129

Association between serum vitamin B₆ concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study

BMJ Open. 2019 Jul 4;9(7):e028129. doi: 10.1136/bmjopen-2018-028129.

Authors

Jing Wang^#^{1

2}, Lin Chen^#^{1

2}, Yan Zhang^{1

2}, Chen-Guang Li^{1

2}, Hao Zhang^{1

2}, Qiang Wang^{1

2}, Xiaofeng Qi^{1

2}, Liang Qiao^{1

2}, Wei-Wei Da^{1

2}, Xue-Jun Cui^{1

2}, Sheng Lu^{1

2}, Yong-Jun Wang^{1

2

3}, Bing Shu^{1

2}

Affiliations

¹ Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Key Laboratory, Ministry of Education of China, Shanghai, China.
³ Shanghai University of Traditional Chinese Medicine, Shanghai, China.

^# Contributed equally.

Abstract

Objective: To determine the relationship between serum vitamin B₆ (Vit B₆) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older people in China.

Design: The present study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study.

Setting and participants: A total of 1829 residents (men ≥50 years and women ≥45 years) from two subdistricts were recruited from July 2015 to February 2016 in Shanghai, China.

Measures: Recruited residents were grouped (control, osteopenia and osteoporosis) according to their lumbar spine bone mineral density, measured through dual-energy X-ray absorptiometry. Serum Vit B₆ concentrations, bone turnover marker concentrations and calcium and phosphorus metabolism parameters were assessed.

Results: No significant linear trend between serum Vit B₆ concentrations and lumbar bone mass was observed in the men. In the women, the average osteoporosis risk was 61% higher at serum Vit B₆ concentrations of <19.2 μg/L than at those of >26.9 μg/L (OR 1.61, 95% CI 1.00 to 2.58). However, there was no significance after controlling of serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration, respectively. In the osteoporotic women, the serum Vit B₆ concentration was significantly negatively correlated to concentrations of bone turnover marker including N-terminal propeptide of type I collagen, β-C-terminal telopeptide of type I collagen and osteocalcin. It was also positively related to the serum 25-hydroxy-vitamin D concentration and inversely related to the serum parathyroid hormone concentration.

Conclusions: A relatively low serum Vit B₆ concentration, even in the normal range, may be a risk factor for osteoporosis in postmenopausal women, which is dependent on serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration.

Trial registration number: NCT02958020; Post-results.

Keywords: bone mineral density; osteoporosis; postmenopausal osteoporosis; vitamin B-6; vitamin D.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Bone Density / physiology
Case-Control Studies
China
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Osteoporosis / blood*
Osteoporosis / physiopathology
Prospective Studies
Vitamin B 6 / blood*

Substances

Vitamin B 6

Associated data

ClinicalTrials.gov/NCT02958020