Contortamide, a new anti-colon cancer cerebroside and other constituents from Tabernaemontana contorta Stapf (Apocynaceae)

Guy R Ebede; Joseph T Ndongo; Joséphine N Mbing; Hector C M Kenfack; Dieudonné E Pegnyemb; Christian G Bochet

doi:10.1080/14786419.2019.1636243

Contortamide, a new anti-colon cancer cerebroside and other constituents from Tabernaemontana contorta Stapf (Apocynaceae)

Nat Prod Res. 2021 Jun;35(11):1757-1765. doi: 10.1080/14786419.2019.1636243. Epub 2019 Jul 5.

Authors

Guy R Ebede^{1

2}, Joseph T Ndongo³, Joséphine N Mbing¹, Hector C M Kenfack⁴, Dieudonné E Pegnyemb¹, Christian G Bochet²

Affiliations

¹ Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
² Department of Chemistry, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
³ Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé, Cameroon.
⁴ Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

PMID: 31274013
DOI: 10.1080/14786419.2019.1636243

Abstract

A new cerebroside, Contortamide (1) together with nine known compounds spegatrine (2), affinisine (3), Nb-methylaffinisine (4), ursolic acid (5), α-amyrin (6), bauerenol acetate (7), lupeol (8), betulinic acid (9) and β-sitosterolglycoside (10) were isolated from the trunk bark of Tabernaemontana contorta Stapf. The new compound 1 showed significant activity against Caco-2 colon cancer cells with the MTT method. Compounds 1-4 and 6-9 were isolated for the first time from this species.

Keywords: Apocynaceae; Contortamide; Tabernaemontana contorta Stapf; colon cancer.

MeSH terms

Antineoplastic Agents / pharmacology*
Caco-2 Cells
Cerebrosides / pharmacology*
Colonic Neoplasms / pathology*
Humans
Plant Extracts / pharmacology*
Tabernaemontana / chemistry*

Substances

Antineoplastic Agents
Cerebrosides
Plant Extracts