Hemodynamic effects of portable non-invasive ventilation in healthy men

Nikolaos Chynkiamis; Matthew Armstrong; James Manifield; Emily Hume; Caroline Reilly; Andrea Aliverti; Alasdair F O'Doherty; Ioannis Vogiatzis

doi:10.1016/j.resp.2019.06.005

Hemodynamic effects of portable non-invasive ventilation in healthy men

Respir Physiol Neurobiol. 2019 Oct:268:103248. doi: 10.1016/j.resp.2019.06.005. Epub 2019 Jul 1.

Authors

Nikolaos Chynkiamis¹, Matthew Armstrong¹, James Manifield¹, Emily Hume¹, Caroline Reilly², Andrea Aliverti³, Alasdair F O'Doherty¹, Ioannis Vogiatzis⁴

Affiliations

¹ Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle Upon-Tyne, NE1 8ST, UK.
² Carnegie School of Sport, Leeds Beckett University, Leeds, UK.
³ Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
⁴ Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle Upon-Tyne, NE1 8ST, UK. Electronic address: ioannis.vogiatzis@northumbria.ac.uk.

PMID: 31271841
DOI: 10.1016/j.resp.2019.06.005

Abstract

VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH₂O). Fixed pressures may cause circulatory compromise. We investigated the circulatory effects of pNIV during normal breathing (NB) and after Eucapnic Voluntary Hyperpnoea trials (EVH) sustained at 80% MVV. In a balanced order sequence, 10 healthy men performed four trials on one visit: 1-min of pNIV (intervention) or 1-min quiet breathing (QB) during NB; and 1-min pNIV (intervention) or 1-min QB during recovery from 3-min EVH. Compared to QB, pNIV application was associated with greater cardiac output (CO: 1.6 ± 1.9 L.min^-1; P = 0.03). One minute into recovery from EVH, pNIV caused greater CO (2.2 ± 1.6 L.min^-1; P = 0.01) compared to QB. Mean blood pressure was not different with pNIV compared to control. pNIV increased thoracoabdominal volumes and breathing frequency during NB and recovery from EVH. pNIV application does not induce adverse hemodynamic effects in healthy men.

Keywords: Central haemodynamic responses; Non-invasive ventilation; Operational chest wall volumes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Blood Pressure / physiology
Hemodynamics / physiology*
Humans
Male
Noninvasive Ventilation* / adverse effects
Noninvasive Ventilation* / instrumentation
Respiratory Muscles / physiology*
Respiratory Physiological Phenomena*
Young Adult