Cytotoxic 19,20-epoxycytochalasans from endophytic fungus Xylaria cf. curta

Fitoterapia. 2019 Sep:137:104253. doi: 10.1016/j.fitote.2019.104253. Epub 2019 Jul 2.

Abstract

Nine new 19,20-epoxycytochalasans (1-9) were isolated from the rice fermentation extracts of endophytic fungus Xylaria cf. curta, along with four known compounds 19,20-epoxycytochalasin C (10), 18-desoxy-19,20-epoxycytochalasin C (11), 19,20-epoxycytochalasin D (12) and 5,6-dihydro-7-oxo-19,20-epoxycytochalasin C (13). Their structures and absolute configurations were determined by 1D and 2D NMR, HRESIMS, X-ray diffraction and ECD calculation. The cytotoxicity of obtained compounds (1-13) was evaluated against human cancer cell lines HL-60, A549, SMMC-7721, MCF-7, and SW480. Remarkably, compound 10 showed significant specific cytotoxicity against HL-60 cell lines with IC50 value of 1.11 μM.

Keywords: 19,20-Epoxycytochalasan; Cytotoxicity; Endophytic fungus; Xylaria cf. curta.

MeSH terms

  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cytochalasins / isolation & purification
  • Cytochalasins / pharmacology*
  • Endophytes / chemistry
  • Humans
  • Molecular Structure
  • Xylariales / chemistry*

Substances

  • Antineoplastic Agents
  • Cytochalasins