Abstract
Hypoxia-related resistance is one of the main challenges for photodynamic therapy to overcome. This highlight discusses a few current works on possible ways to overcome this problem by in situ oxygen generation in the hypoxic core of tumours.
Keywords:
hypoxic tumors; nanocomposites; oxygen generation; photodynamic therapy; photoirradiation.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Doxorubicin / therapeutic use
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Humans
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Infrared Rays
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Nanocomposites / radiation effects
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Nanocomposites / therapeutic use*
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Nanoparticles / radiation effects
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Nanoparticles / therapeutic use*
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Neoplasms / drug therapy*
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Oxygen / metabolism*
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Photochemotherapy / methods
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Photosensitizing Agents / radiation effects
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Photosensitizing Agents / therapeutic use
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Tumor Hypoxia / drug effects*
Substances
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Antineoplastic Agents
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Photosensitizing Agents
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Doxorubicin
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Oxygen