In-Situ Oxygen-Evolving Photoactive Nanococktail: The Future of Hypoxic Tumour Photodynamic Therapy

Chembiochem. 2019 Sep 16;20(18):2322-2323. doi: 10.1002/cbic.201900387. Epub 2019 Jul 19.

Abstract

Hypoxia-related resistance is one of the main challenges for photodynamic therapy to overcome. This highlight discusses a few current works on possible ways to overcome this problem by in situ oxygen generation in the hypoxic core of tumours.

Keywords: hypoxic tumors; nanocomposites; oxygen generation; photodynamic therapy; photoirradiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Doxorubicin / therapeutic use
  • Humans
  • Infrared Rays
  • Nanocomposites / radiation effects
  • Nanocomposites / therapeutic use*
  • Nanoparticles / radiation effects
  • Nanoparticles / therapeutic use*
  • Neoplasms / drug therapy*
  • Oxygen / metabolism*
  • Photochemotherapy / methods
  • Photosensitizing Agents / radiation effects
  • Photosensitizing Agents / therapeutic use
  • Tumor Hypoxia / drug effects*

Substances

  • Antineoplastic Agents
  • Photosensitizing Agents
  • Doxorubicin
  • Oxygen