Tumor Cholesterol Up, T Cells Down

Cell Metab. 2019 Jul 2;30(1):12-13. doi: 10.1016/j.cmet.2019.06.007.

Abstract

Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study by Ma et al. (2019) reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • CD8-Positive T-Lymphocytes
  • Cholesterol
  • Endoplasmic Reticulum Stress
  • Humans
  • Neoplasms*
  • Tumor Microenvironment*

Substances

  • Cholesterol