The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance

Tzong-Hsien Lee; Vinzenz Hofferek; Frances Separovic; Gavin E Reid; Marie-Isabel Aguilar

doi:10.1016/j.cbpa.2019.05.025

The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance

Curr Opin Chem Biol. 2019 Oct:52:85-92. doi: 10.1016/j.cbpa.2019.05.025. Epub 2019 Jun 28.

Authors

Tzong-Hsien Lee¹, Vinzenz Hofferek², Frances Separovic², Gavin E Reid³, Marie-Isabel Aguilar⁴

Affiliations

¹ Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
² School of Chemistry, Bio21 Institute, University of Melbourne, VIC 3010, Australia.
³ School of Chemistry, Bio21 Institute, University of Melbourne, VIC 3010, Australia; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: gavin.reid@unimelb.edu.au.
⁴ Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia. Electronic address: mibel.aguilar@monash.edu.

PMID: 31260926
DOI: 10.1016/j.cbpa.2019.05.025

Abstract

This review provides an analysis of the role that membrane composition and structure plays in the resistance of microorganisms to antimicrobial peptides (AMPs). We describe the current models of membrane disruption caused by AMPs and the changes in the structural properties that microbial membranes undergo in response to AMPs. This is followed by an outline of how the phospholipid composition of microbial membranes contributes to the changes in membrane bilayer structure and how the composition can be analysed in significant detail by modern lipidomic techniques. Finally, we discuss the challenges to fully analyse microbial membrane composition and structure that may occur during the development of resistance to AMPs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antimicrobial Cationic Peptides / metabolism
Antimicrobial Cationic Peptides / pharmacology*
Bacteria / metabolism*
Cell Membrane / metabolism
Drug Resistance, Bacterial*
Lipidomics*
Protein Binding

Substances

Antimicrobial Cationic Peptides