General methods to prepare chiral N-heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2- and 4-substituted tetrahydro-quinolones, dihydro-4-pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.
Keywords: Grignard reagent; Michael addition; alkaloids; asymmetric catalysis; copper.
© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.