Background: Clinically appearing early caries are referred to as white spot lesions (WSLs). These lesions compromise esthetics and precede cavitation; therefore, they must be halted by effective materials.
Aim: To evaluate and compare the depth of penetration and effect of resin infiltration system (Icon) and other conventional pit and fissure sealants (Clinpro and Embrace) on enamel surface properties of WSLs.
Methodology: Freshly extracted premolars were obtained. Enamel surfaces were treated with resin infiltrant and fissure sealant. Depth of penetration and surface roughness of specimens were measured with an optical profilometer. Microhardness was determined by a Vickers' hardness tester.
Statistical analysis: Normality of the data was checked by Shapiro-Wilk test. Inferential statistics were performed using one-way analysis of variance. Post hoc pairwise comparison was done using post hoc Tukey's test.
Results: Icon resin infiltrant showed the highest depth of penetration and microhardness followed in descending order by Embrace and Clinpro whereas Clinpro was found to cause maximum surface roughness followed in descending order by Embrace and Icon.
Conclusion: The resin infiltration technique for treating WSLs seems adjusted to the philosophy of minimally invasive dentistry in a single appointment, making it beneficial for the patients, especially children.
Keywords: Icon; pit and fissure sealants; remineralization; white spot lesion.