Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference (PcvaCO2/CavO2) reflects microcirculatory oxygenation alterations in early septic shock

Abstract

Purpose: To explore the relationship between central venous-to-arterial carbon dioxide difference (P_cvaCO₂), P_cvaCO₂/arterial-venous oxygen content difference ratio (P_cvaCO₂/C_avO₂) and the microcirculatory status, evaluated by using near-infrared spectroscopy, in septic shock patients.

Methods: Observational study in a 30-bed mixed ICU. Fifty septic shock patients within the first 24 h of ICU admission were studied. After restoration of mean arterial pressure, hemodynamic, metabolic and microcirculatory parameters were simultaneously evaluated. Local tissue oxygen saturation (StO₂), and local hemoglobin index (THI) were measured on the thenar eminence by means of near-infrared spectroscopy. A transient vascular occlusion test was performed in order to obtain StO₂ deoxygenation rate (DeO₂), local oxygen consumption (nirVO₂), and reoxgenation rate (ReO₂).

Results: At inclusion, increased P_cvaCO₂ values were associated with lower StO₂ and THI, whereas increased P_cvaCO₂/C_avO₂ values were associated with lower DeO₂, nirVO₂, and ReO₂. Multiple regression models confirmed the association between P_cvaCO₂/C_avO₂ and nirVO₂, while P_cvaCO₂ was only related to CI, and not to microcirculatory parameters.

Conclusions: In a population of early septic shock patients, increases in P_cvaCO₂ and P_cvaCO₂/C_avO₂ reflected different alterations at the microcirculatory level. While P_cvaCO₂ was related to global flow, the P_cvaCO₂/C_avO₂ ratio was associated to impaired local oxygen utilization and diminished microvascular reactivity.

Keywords: Circulatory shock; Hemodynamic monitoring; Microcirculation; Near-infrared spectroscopy; Tissue oxygenation; Venous-to-arterial carbon dioxide difference.