The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

Jiangli Zhu; Jing Zhang; Yan Wang; Jianping Chen; Xiaopeng Li; Xiangling Liu; Eryan Kong; Shao B Su; Zhongjian Zhang

doi:10.2174/1566524019666190627122655

The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

Curr Mol Med. 2019;19(8):589-596. doi: 10.2174/1566524019666190627122655.

Authors

Jiangli Zhu¹, Jing Zhang², Yan Wang³, Jianping Chen², Xiaopeng Li¹, Xiangling Liu¹, Eryan Kong⁴, Shao B Su^{1

2}, Zhongjian Zhang⁴

Affiliations

¹ The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453000, China.
² State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
³ Guangdong Science and Technology Library (Guangdong Institute of Scientific and Technical Information and Development Strategy), China.
⁴ Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan, 453000, China.

PMID: 31244436
DOI: 10.2174/1566524019666190627122655

Abstract

Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.

Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.

Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro.

Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

Keywords: Angiogenesis; IL-38; cytokine; inflammation; interleukin; neovascularization..

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Topical
Animals
Cell Movement
Cells, Cultured
Corneal Neovascularization / drug therapy*
Corneal Neovascularization / etiology
Cytokines / biosynthesis
Cytokines / genetics
Endothelial Cells / drug effects
Humans
Interleukin-1 / antagonists & inhibitors
Interleukin-1 / pharmacology
Interleukin-1 / physiology*
Interleukin-1 / therapeutic use
Keratitis / chemically induced
Keratitis / complications
Mice
Mice, Inbred C57BL
Real-Time Polymerase Chain Reaction
Recombinant Proteins / therapeutic use
Retina / cytology
Sodium Hydroxide / toxicity
Vascular Endothelial Growth Factor A / pharmacology

Substances

Cytokines
Il1f10 protein, mouse
Interleukin-1
Recombinant Proteins
Vascular Endothelial Growth Factor A
Sodium Hydroxide