Pyranoflavanones and Pyranochalcones from the Fruits of Amomum tsao-ko

J Nat Prod. 2019 Jul 26;82(7):1886-1892. doi: 10.1021/acs.jnatprod.9b00155. Epub 2019 Jun 25.

Abstract

Eight new geranylated and farnesylated pyranoflavanones (1-8) and two new farnesylated pyranochalcones (9 and 10) were isolated from the methanolic extract of the fruits of Amomum tsao-ko. Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC50 values ranging from 10.6 to 41.5 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amomum / chemistry*
  • Animals
  • Chalcones / chemistry
  • Chalcones / isolation & purification*
  • Flavanones / chemistry
  • Flavanones / isolation & purification*
  • Mice
  • Molecular Structure
  • Pyrans / chemistry*
  • RAW 264.7 Cells
  • Spectrum Analysis / methods

Substances

  • Chalcones
  • Flavanones
  • Pyrans