Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review

Curr Protein Pept Sci. 2019;20(9):885-892. doi: 10.2174/1389203720666190626160057.

Abstract

Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include coadministration with nanoparticles and/or classic drugs.

Keywords: Mycobacterium tuberculosis; Tuberculosis; antimicrobial peptides; natural CAMPs; synthetic CAMPs..

Publication types

  • Review

MeSH terms

  • Antimicrobial Cationic Peptides / pharmacology*
  • Biological Products / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Tuberculosis / drug therapy*
  • Tuberculosis / microbiology*

Substances

  • Antimicrobial Cationic Peptides
  • Biological Products