Cause-specific death assessment of patients with stage I small-cell lung cancer: a competing risk analysis

Future Oncol. 2019 Jul;15(21):2479-2488. doi: 10.2217/fon-2018-0888. Epub 2019 Jun 26.

Abstract

Aim: Stage I small-cell lung cancer (SCLC) is a potentially curable disease that needs timely and multidisciplinary management. The aim of this study was to evaluate the probability of cause-specific mortality for patients with stage I SCLC. Material & methods: We identified patients in the SEER database and constructed a proportional subdistribution hazard model to evaluate cancer-specific mortality. A nomogram was built based on Fine and Gray competing risk regression model. Results: A total of 864 stage I SCLC patients were identified. The 5-year cumulative incidence of SCLC-specific mortality was 56.2%, while that for other causes of death was 17.3%. The c-index for the prognostic prediction model was 0.66. Besides, the nomogram was well calibrated. Conclusion: Our nomogram might serve as a reference for clinicians when evaluating the prognosis of stage I SCLC.

Keywords: SCLC; SEER; cancer-specific death; competing risk nomogram.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cause of Death
  • Combined Modality Therapy
  • Female
  • Humans
  • Incidence
  • Lung Neoplasms / epidemiology*
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / therapy
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Nomograms
  • Risk Assessment
  • Risk Factors
  • SEER Program
  • Small Cell Lung Carcinoma / epidemiology*
  • Small Cell Lung Carcinoma / pathology*
  • Small Cell Lung Carcinoma / therapy
  • Treatment Outcome