Correlation between MDSC and Immune Tolerance in Transplantation: Cytokines, Pathways and Cell-cell Interaction

Tianying Yang; Jiawei Li; Ruimin Li; Chunchen Yang; Weitao Zhang; Yue Qiu; Cheng Yang; Ruiming Rong

doi:10.2174/1566523219666190618093707

Correlation between MDSC and Immune Tolerance in Transplantation: Cytokines, Pathways and Cell-cell Interaction

Curr Gene Ther. 2019;19(2):81-92. doi: 10.2174/1566523219666190618093707.

Authors

Tianying Yang^{1

2}, Jiawei Li^{1

2}, Ruimin Li^{2

3}, Chunchen Yang⁴, Weitao Zhang^{1

2}, Yue Qiu⁵, Cheng Yang^{1

2}, Ruiming Rong^{1

2

4}

Affiliations

¹ Department of Urology, ZhongShan Hospital, Fudan University, Shanghai, China.
² Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
³ Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China.
⁴ Department of Transfusion, Zhongshan Hospital, Fudan University, Shanghai, China.
⁵ Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

PMID: 31237207
DOI: 10.2174/1566523219666190618093707

Abstract

MDSCs play an important role in the induction of immune tolerance. Cytokines and chemokines (GM-CSF, IL-6) contributed to the expansion, accumulation of MDSCs, and MDSCs function through iNOS, arginase and PD-L1. MDSCs are recruited and regulated through JAK/STAT, mTOR and Raf/MEK/ERK signaling pathways. MDSCs' immunosuppressive functions were realized through Tregs-mediated pathways and their direct suppression of immune cells. All of the above contribute to the MDSC-related immune tolerance in transplantation. MDSCs have huge potential in prolonging graft survival and reducing rejection through different ways and many other factors worthy to be further investigated are also introduced.

Keywords: CXCR2; GM-CSF; JAK/STAT; Myeloid-derived suppressor cells; immune tolerance; transplantation..

Publication types

Review

MeSH terms

Cell Communication / genetics
Graft Survival / genetics*
Granulocyte-Macrophage Colony-Stimulating Factor / genetics
Humans
Immune Tolerance / genetics*
Immunosuppression Therapy / trends*
Interleukin-6 / genetics
Janus Kinases / genetics
Myeloid-Derived Suppressor Cells / metabolism
Myeloid-Derived Suppressor Cells / transplantation*
Nitric Oxide Synthase Type II / genetics
Receptors, Interleukin-8B / genetics
STAT Transcription Factors / genetics

Substances

CXCR2 protein, human
Interleukin-6
Receptors, Interleukin-8B
STAT Transcription Factors
Granulocyte-Macrophage Colony-Stimulating Factor
Nitric Oxide Synthase Type II
Janus Kinases