C1q/TNF-related protein-3 and glucose homeostasis

Diabetes Metab Syndr. 2019 May-Jun;13(3):1923-1927. doi: 10.1016/j.dsx.2019.04.047. Epub 2019 Apr 25.

Abstract

Adipokines are cytokines produced by adipocytes that may mediate inflammatory processes, whilst adipocyte-derived proteins may have the converse effect. C1q/TNF-related protein-3 or CTRP3 is a novel adipokine that is expressed and released by most types of human tissues including adipose tissue. This adipokine, considered as an adiponectin, can normalize blood glucose by several mechanisms. In addition, it can modulate the expression/secretion of other cytokine and adipokines leading to lower insulin resistance in peripheral tissues. Beneficial effects of CTRP3 against hyperglycemia-induced complications in the kidney and eye have been reported. In this review, we have presented the latest findings on the in vitro and in vivo hypoglycemic effects of CTRP3, followed by the findings on the preventive/therapeutic effects of CTRP3 adipokines against diabetes related complications.

Keywords: Adipokine; Adiponectin; C1q/TNF-Related protein-3; CTRP3; Glut-4; Inflammation; Insulin resistance; Insulin sensitivity; TNF-α.

Publication types

  • Review

MeSH terms

  • Blood Glucose / analysis
  • Diabetes Complications / etiology
  • Diabetes Complications / metabolism
  • Diabetes Complications / prevention & control*
  • Homeostasis*
  • Humans
  • Hyperglycemia / etiology
  • Hyperglycemia / metabolism
  • Hyperglycemia / prevention & control*
  • Insulin Resistance
  • Tumor Necrosis Factors / metabolism*

Substances

  • Blood Glucose
  • C1QTNF3 protein, human
  • Tumor Necrosis Factors