Corneal melt secondary to eosinophilic granulomatosis with polyangiitis

BMJ Case Rep. 2019 Jun 21;12(6):e229859. doi: 10.1136/bcr-2019-229859.

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare antineutrophil cytoplasmic antibody-associated vasculitis that can affect any organ system. It is most often characterised by chronic airway inflammation along with prominent peripheral blood eosinophilia, although the disease can affect the cardiovascular, gastrointestinal, renal or central nervous systems. Ocular manifestations are uncommon and when they do occur, are varied in their clinical presentations. To the best of our knowledge, this is the first case of corneal melt secondary to EGPA to have been reported.

Keywords: eye; ophthalmology; respiratory medicine.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Antibodies, Antineutrophil Cytoplasmic
  • Ciprofloxacin / therapeutic use*
  • Corneal Perforation / microbiology
  • Corneal Perforation / pathology*
  • Corneal Perforation / therapy
  • Corneal Ulcer / microbiology
  • Corneal Ulcer / pathology*
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / physiopathology
  • Humans
  • Male
  • Treatment Outcome
  • Vision Disorders / drug therapy
  • Vision Disorders / etiology*
  • Vision Disorders / microbiology
  • Vision Disorders / physiopathology

Substances

  • Anti-Bacterial Agents
  • Antibodies, Antineutrophil Cytoplasmic
  • Ciprofloxacin